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Aging & AD/PD & EVs
Aging increases the risk of diseases such as cancer, diabetes, cardiovascular disease, stroke, and last but not least neurodegenerative diseases. The molecular and cellular changes that occur during aging lead to neuronal degeneration in age-related neurological diseases such as Alzheimer's or Parkinson's diseases. We focus on elucidating the cellular and biochemical signaling mechanisms that lead to neuronal degeneration and brain aging. We also focus on identifying new AD/PD risk factors by RNA-seq and ATAC-seq in patient-derived neurons and investigating the roles of extracellular vesicles in the pathogenesis of AD/PD. In order to develop therapeutics for AD/PD, we are engineering extracellular vesicles to load and deliver diverse therapeutics proteins, including CRISPR-based tools, to the brain.
Drug discovery projects spanning the range from target validation and initial high-throughput screening to lead identification
CRISPR screening for identifying novel genes that play significant roles in tauopathy and amyloidopathy
Generation of patient-derived iPSC isogenic lines for APOE to elucidate the roles of APOE in the pathogenesis of AD
Investigating the roles of extracellular vesicles in the pathogenesis of AD
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