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Research Interests


Alzheimer’s disease (AD) is the most common form of dementia for there is still no cure or effective treatment. Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons. We focus on identifying new AD/PD risk factors by RNA-seq and ATAC-seq in patient-derived neurons, repurposing FDA-approved drugs using diverse screening and reporter systems, and developing nanomedicine for AD/PD by using engineered extracellular vesicles. We also focus on elucidating the roles of extracellular vesicles in the pathogenesis of AD/PD.

On-Going Projects

Alzheimer's disease

  • Drug discovery projects spanning the range from target validation and initial high-throughput screening to lead identification

  • CRISPR screening for identifying novel genes that play significant roles in tauopathy and amyloidopathy

  • Generation of patient-derived iPSC isogenic lines for APOE to elucidate the roles of APOE in the pathogenesis of AD

  • Investigating the roles of extracellular vesicles in the pathogenesis of AD

Parkinson's disease

  • Developing dopaminergic neuron targeting ADSC-derived extracellular vesicles 

  • Developing engineered extracellular vesicles carrying therapeutic proteins for PD

  • Investigating the molecular mechanism underpinning the pathogenesis of PD

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