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Engineered small extracellular vesicles displaying ACE2 variants on the surface protect against SARS-CoV-2 infection

Kim HK*, Cho J*, Kim E, Kim J, Yang JS, Kim KC, Lee JY, Shin Y, Palomera LF, Park J, Baek SH, Bae HG, Cho Y, Han J, Sul JH, Lee J, Park JH, Cho YW, Lee W†, and Jo DG†.

J Extracell Vesicles    2022

Extracellular vesicles from adipose tissue-derived stem cells alleviate osteoporosis through osteoprotegerin and miR-21-5p

Lee KS*, Lee J*, Kim HK, Yeom SH, Woo CH, Jung YJ, Yun YE, Park SY, Han J, Kim E, Sul JH, Jung JM, Park JH, Choi JS†, Cho YW†, and Jo DG†

J Extracell Vesicles    2021

Alzheimer's disease-causing presenilin-1 mutations have deleterious effects on mitochondrial function

Han J, Park H, Maharana C, Gwon AR, Park J, Baek SH, Bae HG, Cho Y, Kim HK, Sul JH, Lee J, Kim E, Kim J, Cho YE, Park SY, Palomera LF, Arumugam TV, Mattson MP†, Jo DG†

Theranostics     2021

Reactive oxygen species-responsive dendritic cell-derived exosomes for rheumatoid arthritis

Lee ES, Sul JH, Shin JM, Shin S, Lee JA, Kim HK, Cho Y, Ko H, Son S, Lee J, Park S, Jo DG†, Park JH†

Acta Biomater.    2021

O-GlcNAcylation ameliorates the pathological manifestations of Alzheimer's disease by inhibiting necroptosis

Park J, Ha HJ, Chung ES, Baek SH, Cho Y, Kim HK, Han J, Sul JH, Lee J, Kim E, Kim J, Yang YR, Park M, Kim SH, Arumugam TV, Jang H, Seo SW, Suh PG, Jo DG

Sci. Adv.     2021

Cell reprogramming using extracellular vesicles from differentiating stem cells into white/beige adipocytes

Jung YJ*, Kim HK*, Cho Y, Choi JS, Woo CH, Lee KS, Sul JH, Lee CM, Han J, Park JH, Jo DG†, Cho YW†

Sci. Adv.     2020

Small extracellular vesicles from human adipose-derived stem cells attenuate cartilage degeneration

Woo CH, Kim HK, Jung GY, Jung YJ, Lee KS, Yun YE, Han J, Lee J, Kim WS, Choi JS, Yang S, Park JH, Jo DG†, Cho YW†

J Extracell Vesicles     2020

Neuronal Aquaporin 1 inhibits amyloidogenesis by suppressing the interaction between beta-secretase and amyloid precursor protein

Park J, Madan M, Chigurupati S, Baek SH, Cho Y, Mughal MR, Yu A, Chan SL, Pattisapu JV, Mattson MP, Jo DG

J Gerontol A Biol Sci Med Sci     2020

O-GlcNAcylation as a therapeutic target for Alzheimer's disease

Park J, Lai MKP, Arumugam TV†, Jo DG†

Neuromolecular Med     2020

Intermittent fasting increases adult hippocampal neurogenesis

Park J, Lai MKP, Arumugam TV†, Jo DG†

Brain Behav     2020

NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer's models

Bahn G*, Park JS*, Yun UJ*, Lee YJ, Choi Y, Park JS, Baek SH, Choi BY, Cho YS, Kim HK, Han J, Sul JH, Baik SH, Lim J, Wakabayashi N, Bae SH, Han JW, Arumugam TV, Mattson MP†, Jo DG†

Proc Natl Acad Sci U S A     2019

Therapeutic approaches to Alzheimer's disease through modulation of NRF2

Bahn G, Jo DG

Neuromolecular Med     2019

Mulberry fruit extract ameliorates nonalcoholic fatty liver disease (NAFLD) through inhibition of mitochondrial oxidative stress in rats

Yang DK, Jo DG

Evid Based Complement Alternat Med     2018

Inhibition of Notch1 induces population and suppressive activity of regulatory T cell in inflammatory arthritis

Choi BY, Choi Y, Park JS, Kang LJ, Baek SH, Park JS, Bahn G, Cho Y, Kim HK, Han J, Sul JH, Baik SH, Hyun DH, Arumugam TV, Yang S, Han JW, Kang YM, Cho YW, Park JH, Jo DG

Theranostics     2018

Notch signaling and neuronal death in stroke

Arumugam TV†, Baik SH, Balaganapathy P, Sobey CG, Mattson MP, Jo DG†.

Prog Neurobiol     2018

Inhibition of Drp1 ameliorates synaptic depression, Aβ deposition, and cognitive impairment in an Alzheimer's disease model

Baek SH, Park SJ, Jeong JI, Kim SH, Han J, Kyung JW, Baik SH, Choi Y, Choi BY, Park JS, Bahn G, Shin JH, Jo DS, Lee JY, Jang CG, Arumugam TV, Kim J, Han JW, Koh JY, Cho DH, Jo DG

J Neurosci     2017

Interplay between Notch and p53 promotes neuronal cell death in ischemic stroke

Balaganapathy P, Baik SH, Mallilankaraman K, Sobey CG, Jo DG†, Arumugam TV†

J Cereb Blood Flow Metab    2017

Notch1 deficiency decreases hepatic lipid accumulation by induction of fatty acid oxidation.

Song NJ, Yun UJ, Yang S, Wu C, Seo CR, Gwon AR, Baik SH, Choi Y, Choi BY, Bahn G, Kim S, Kwon SM, Park JS, Baek SH, Park TJ, Yoon K, Kim BJ, Mattson MP, Lee SJ, Jo DG†, Park KW†

Sci Rep    2016

Emerging roles of the γ-secretase-notch axis in inflammation

Cheng YL, Choi Y, Sobey CG, Arumugam TV, Jo DG†

Pharmacol Ther    2015

Pin1 promotes neuronal death in stroke by stabilizing Notch intracellular domain

Baik SH, Fane M, Park JH, Cheng YL, Yang-Wei Fann D, Yun UJ, Choi Y, Park JS, Chai BH, Park JS, Back SH, Jeong JI, Jang YJ, Bahn G, Lee JY, Li YI, Sobey CG, Uchida T, Park JH, Kim HT, Tang SC, Arumugam TV†, Jo DG†

Ann Neuro   2015

Notch1 targeting siRNA delivery nanoparticles for rheumatoid arthritis therapy

Kim MJ, Park JS, Lee SJ, Jang J, Park JS, Back SH, Bahn G, Park JH, Kang YM, Kim SH, Kwon IC, Jo DG†, Kim K†

J Control Release   2015

Evidence that neuronal Notch-1 promotes JNK/c-Jun activation and cell death following ischemic stress

Cheng YL, Choi Y, Seow WL, Manzanero S, Sobey CG, Jo DG†, Arumugam TV†

Brain Res   2014

Hyaluronan nanoparticles bearing γ-secretase inhibitor: in vivo therapeutic effects on rheumatoid arthritis

Heo R, Park JS, Jang HJ, Kim SH, Shin JM, Suh YD, Jeong JH, Jo DG† Park JH†

J Control Release   2014

A hyaluronic acid-methotrexate conjugate for targeted therapy of rheumatoid arthritis

Shin JM, Kim SH, Thambi T, You DG, Jeon J, Lee JO, Chung BY, Jo DG†, Park JH†

Chem Commun (Camb)   2014

Evidence that Collaboration between HIF-1α and Notch-1 Promotes Neuronal Cell Death in Ischemic Stroke

Cheng YL, Park JS, Manzanero S, Choi Y, Baik SH, Okun E, Gelderblom M, Fann DY, Magnus T, Launikonis BS, Mattson MP, Sobey CG, Jo DG†, Arumugam TV†

Neurobiol Dis   2014

Inhibition of Notch signalling ameliorates experimental inflammatory arthritis

Park JS, Kim SH, Kim K, Jin CH, Choi KY, Jang J, Choi Y, Gwon AR, Baik SH, Yun UJ, Chae SY, Lee S, Kang YM, Lee KC, Arumugam TV, Mattson MP, Park JH, Jo DG

Ann Rheum Dis   2013


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