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Research Interests
Extracellular vesicles
Extracellular vesicles (EVs), nanosized (30-150 nm) membrane vesicles that are naturally secreted by various types of cells, are emerging as one of the most promising nanocarriers for bioactive molecules. We focus on engineering EVs to develop novel EV-based intracellular protein delivery systems which can be applied to various diseases associated with specific protein deficiencies or gene mutations. Using these systems, we attempt to deliver diverse CRISPR-based tools to induce in vivo gene or epigenome editing, which can be applied to diverse neurodegenerative diseases.
On-Going Projects
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Developing novel EV-based intracellular protein delivery systems which can be applied to various diseases associated with specific protein deficiencies or gene mutations
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Delivering CRISPR-based tools using engineered EVs to induce gene editing in AD mouse models
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Delivering CRISPR-based tools using engineered EVs to induce epigenome editing in AD mouse models
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Developing engineered-EVs displaying a decoy receptor for various diseases
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